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GLUC-010A
Glucagon-Like Peptide I (7-36), amide, human
His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Size:0.5mg
P1(RMB):398
MW:3297.7
One letter sequence:HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Molecular Formula:C149H226N40O45
Description:GLp-1 fragment that is isolated from the lower small intestine and is presently regarded to be the most important incretin hormone. It shows a strong insulinotropic effect that is mediated by receptors expressed in the pancreatic β-cells. It is proposed to be a novel therapeutic strategy for non-insulin-dependent (type 2) diabetes mellitus and associated neuropathy.
Literature Reference:G. Bell et al., Nature, 304, 368 (1983)
Cas:[107444-51-9]
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